Intravenous iron-dextran: therapeutic and experimental possibilities. We have found the lower dose to be better tolerated in the second half of gestation. Avoid or Use Alternate Drug. Before using, check this product visually for particles or discoloration. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Monitor for signs and symptoms of hypotension following each administration of Venofer. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Drug Des Devel Ther; 5: 5160. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. You may report side effects to Health Canada at 1-866-234-2345. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Intravenous iron sucrose for children with iron deficiency anemia: a PDF IRON PRODUCT CHOICE AND DOSE CALCULATION - Blood Each mL contains 20 mg of elemental . Corrected Calcium. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Copyright 1993-2021 Dosage Calculator - [100% Free] - Calculators.io Applies only to oral form of both agents. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW PDF Venofer Guidelines for Use 2011 - University Health System Iron sucrose | Drugs | BNF | NICE Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Deferasirox chelates iron. Deferasirox chelates iron. Always ask your health care professional for complete information about this product and your specific health needs. *Repeat dose if iron deficiency anemia reoccurs. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. 1998 Feb;25(1):65-8. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Applies only to oral form of both agents. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Use Caution/Monitor. Applies only to oral form of both agents. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Minor/Significance Unknown. Information last revised December 2022. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Anemia; 2015: 763576. LBW = Lean body weight in kg. ONE DOSE. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Separate by 2 hr. Share cases and questions with Physicians on Medscape consult. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Patients measured hemoglobin can be input in g/dL or mmol/L. Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Last updated on Jun 1, 2022. All Rights Reserved. Dosing Administration & Considerations . Written by ASHP. Anemia; 2015: 763576. Applies only to oral form of both agents. Administer on 5 different occasions over a 14 day period. Applies only to oral form of both agents. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer treatment may be repeated if necessary. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. There are physiological variation in iron reserves such as the decrease during menstruation period. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. iron sucrose decreases levels of manganese by inhibition of GI absorption. Observed Hb = the patients current hemoglobin in g/dl. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Modify Therapy/Monitor Closely. May increase risk of hypotension. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Applies only to oral form of both agents. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Use Caution/Monitor. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Use Caution/Monitor. UpToDate. Use Caution/Monitor. Use Caution/Monitor. The iron formulation choice remains for the clinician to make. This information does not assure that this product is safe, effective, or appropriate for you. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Medicinal forms Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. 1. Applies only to oral form of both agents. All Rights Reserved. Applies only to oral form of both agents. Discard unused portion. Hollands J, Foote E, Rodriguez A. MISSED DOSE: It is important to get each dose of this medication as scheduled. Applies only to oral form of both agents. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Applies only to oral form of both agents. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Each mL contains 20 mg of elemental iron. 1988 May;111(5):566-70. Use Caution/Monitor. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. 1982;13(4):309-21. Minor/Significance Unknown. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. FERAHEME Dosing & Administration - Feraheme This calculator will help pinpoint potential causes of anemia based on Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. commonly, these are "non-preferred" brand drugs or specialty A: Generally acceptable. Human studies not conducted. Applies only to oral form of both agents. This document does not contain all possible drug interactions. Reactions have occurred following the first dose or subsequent doses of Venofer. Minor/Significance Unknown. Avoid or Use Alternate Drug. Initial infusion rate. Use Caution/Monitor. PDF Protocol for the use of Intravenous Iron Dextran (CosmoFer Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Venofer / Products / American Regent Accessed: 4/12/2011. Applies only to oral form of both agents. . Baloxavir may bind to polyvalent cations resulting in decreased absorption. Max Dose. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Applies only to oral form of both agents. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Applies only to oral form of both agents. 2012;2(4):288-335. Reference www.medicines.org.uk Background Applies only to oral form of both agents. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. 2. It can be expressed in mg per ml. Minor/Significance Unknown. Applies only to oral form of both agents. 10th ed. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Applies only to oral form of both agents. Step 2: Calculation and administration of the maximum individual iron dose(s): . There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. David McAuley, Pharm.D. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. PDF PRODUCT MONOGRAPH - pdf.hres.ca Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . J Lab Clin Med; 111(5):566-70. Avoid or Use Alternate Drug. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. A healthcare provider will give you this injection. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Oral and parenteral products - see background option for oral products. IDA diagnosis is based on full blood examination and on the serum ferritin level. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. This site complies with the HONcode standard for trust- worthy health information: verify here. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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