The risk of getting myocarditis from a COVID-19 vaccine is less than 1%. Observed cases of myocarditis reported to VAERS after Moderna dose 2, 7-day risk period (N=216)* Age group, years Females Males Cases of myopericarditis, expected Cases of . COVID-19 vaccines and cardiac inflammation One thing we don't know is the real rate of myocarditis with the original two-dose primary series of Pfizer and Moderna. Shimabukuro TT, Nguyen M, Martin D, DeStefano F. Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS). (2022). You will be subject to the destination website's privacy policy when you follow the link. Potential cases of postvaccine myocarditis were identified based on reports . It is unclear how many of these cases are a direct consequence of the vaccine versus coincidental. Again, females had lower rates for both the first . Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of All information these cookies collect is aggregated and therefore anonymous. Myocarditis after COVID vaccine: What to know about symptoms - USA TODAY mRNA Vaccine Technology: A Promising Idea for Fighting HIV, Testing of mRNA HIV vaccines in humans is underway. Trends in acute myocarditis related pediatric hospitalizations in the United States, 20072016. Among males aged 30 years, 15,300 COVID-19 cases, 4,598 hospitalizations, 1,242 ICU admissions, and 700 deaths could be prevented, compared with three to four expected myocarditis cases after COVID-19 vaccination. Drs Barnett, Ruberg, and Smith reported receiving grants from Pfizer. Law, Y. M., Lal, A. K., Chen, S., ihkov, D., Cooper, L. T., Jr, Deshpande, S., Godown, J., Grosse-Wortmann, L., Robinson, J. D., Towbin, J. In cases of v-safe reports that include possible medically attended health events, CDCs v-safe call center follows up with the vaccine recipient to collect additional information for completion of a VAERS report. Severe problems linked with myocarditis include chest pain, arrhythmias, trouble breathing, ankle or leg swelling, and fainting. For Moderna's vaccine, rates of myocarditis or pericarditis overall were 23 cases per million first doses and 62.5 cases per million second doses. Pericarditisis inflammation of the outer lining of the heart. 2023 Jan 17;11(2):208. doi: 10.3390/vaccines11020208. At the time of this report, 323 of these 484 cases were determined to meet criteria in CDCs case definitions for myocarditis, pericarditis, or myopericarditis by provider interview or medical record review (Table 1). FOIA Dr Soslow reported receiving personal fees from Esperare. Last week, after reviewing data from a clinical . https://www.cdc.gov/vaccinesafety/ensuringsafety/monitoring/cisa/index.html. Data were used for the most recent week not subject to reporting delays prior to the ACIP meeting. Among teenage boys, the rate of myocarditis or pericarditis after infection was at least 50 cases per 100,000 people, compared to at least 22 cases per 100,000 after the second vaccine dose.. Males under age 40 who received the Moderna vaccine were shown to have the highest rates of myocarditis, and the researchers said the study's findings support the idea of recommending. Myocarditis after vaccination against covid-19 | The BMJ Moderna Reveals Slightly Higher Rates of Myocarditis in Young - Yahoo! CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis. of pages found at these sites. The scientists are monitoring the health of a diverse group of people to learn about the long-term effects of COVID, including heart problems. Myocarditis is a rare complication of COVID-19 vaccination. Moderna - 19 case of myocarditis and 19 cases of pericarditis out of 20 million doses given Five people died. The y-axis range differs between panels A and B. U.S. reviewing if Moderna shot tied to higher heart inflammation risk The work group also reviewed a benefit-risk assessment of myocarditis events after receipt of mRNA COVID-19 vaccines, considering recent epidemiology of COVID-19 and sequelae of COVID-19, including myocarditis and multisystem inflammatory syndrome in children (MIS-C). This is a recognised risk with the Comirnaty (Pfizer) and Spikevax (Moderna) vaccines and we are closely monitoring these events. <> While the researchers did observe a higher risk among people that got the Moderna shot, it was still a relatively small risk. These cookies may also be used for advertising purposes by these third parties. CDC continues to recommend that everyone ages 6 months and older get vaccinated for COVID-19. Pillay J, Gaudet L, Wingert A, Bialy L, Mackie AS, Paterson DI, Hartling L. BMJ. Vaccine 2015;33:4398405. Moderna says Covid vaccine for kids, 6 months to age 6, protects Follow-up is ongoing to identify and understand longer-term outcomes after myocarditis occurring after COVID-19 vaccination. The median age of the 323 patients meeting CDCs case definitions was 19 years (range=1229 years); 291 were male, and 32 were female. Annie, F. H., Alkhaimy, H., Nanjundappa, A., & Elashery, A. The rates of myocarditis were highest after the second vaccination dose in adolescent males aged 12 to 15 years (70.7 per million doses of the BNT162b2 vaccine), in adolescent males aged 16 to 17 years (105.9 per million doses of the BNT162b2 vaccine), and in young men aged 18 to 24 years (52.4 and 56.3 per million doses of the BNT162b2 vaccine Because these studies are in their early phases, the results are not ready yet. ACIP also reviewed population-level considerations regarding vaccination. Only about 1 out of 100 cases of heart inflammation linked with COVID-19 vaccines is life-threatening.5 An analysis of 627 cases of vaccine-linked myocarditis worldwide showed that 626 fully recovered and one fatality.7. the rates per million doses were roughly 52 with the Pfizer shots and . Though both complications were rare, data from Ontario show higher rates of myocarditis and pericarditis with the Moderna COVID-19 vaccine than with the Pfizer-BioNTech vaccine, but the rates were lower for both vaccines if the spacing between receiving two doses was extended, according to a study late last week in JAMA Network Open.. Myocarditis is an inflammation of the heart muscle, and . Myocarditis reporting rates were 40.6 cases per million second doses of mRNA COVID-19 vaccines administered to males aged 1229 years and 2.4 per million second doses administered to males aged 30 years; reporting rates among females in these age groups were 4.2 and 1.0 per million second doses, respectively. The benefit-risk analysis can be updated as needed to reflect changes in the COVID-19 pandemic and additional information on the risk for and outcomes of myocarditis after COVID-19 vaccination. Reports of Guillain-Barr Syndrome After COVID-19 Vaccination in the United States. On June 23, 2021, the Advisory Committee on Immunization Practices concluded that the benefits of COVID-19 vaccination to individual persons and at the population level clearly outweighed the risks of myocarditis after vaccination. Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Thank you for taking the time to confirm your preferences. Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices United States, June 2021. CDC says there's likely link between rare heart inflammation in - CNBC I doubt we'll ever know. The most common symptoms are chest pain, fever, fatigue, shortness of breath, and a rapid or irregular pulse. Ho, J. S., Sia, C.-H., Chan, M. Y., Lin, W., & Wong, R. C. (2020). COVID-19 Therapeutics: Use, Mechanism of Action, and Toxicity (Vaccines, Monoclonal Antibodies, and Immunotherapeutics). NHLBI Information & Resources on COVID-19. National Library of Medicine If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. According to the TGA, the current overall estimated rates for the entire population of myocarditis for Pfizer and Moderna are similar - 1.4 cases per 100,000 Pfizer doses versus 1.8 cases per 100,000 Moderna doses. Would you like email updates of new search results? The study showed males younger than 40 years old who received the Moderna vaccine were shown to have the highest rates of myocarditis, which according to the authors, may have implications for choosing specific vaccines for certain populations. You will be subject to the destination website's privacy policy when you follow the link. *** Data collection for race/ethnicity of myocarditis cases is ongoing. Adenoviral Vector-Based Vaccine Platform for COVID-19: Current Status. Parents should speak with their childrens health care providers regarding the benefits and risks of vaccination against COVID-19. No alternatives to mRNA COVID-19 vaccines for adolescents will be available for the foreseeable future, and vaccination of adolescents offers protection against COVID-19 that can be important for returning to educational, social, and extracurricular activities. Here's all the data on myocarditis cases linked to COVID-19 vaccines Reports of myocarditis and pericarditis after vaccination are rare. They also recover normal heart function sooner.12. Pediatrics 2011;127(Suppl 1):S4553. scientist on Monday, every million doses of the Pfizer vaccine administered to 16- and 17-year-old boys would be expected to cause 73 cases of the . **** The risks were assessed as the number of myocarditis patients reported to VAERS that occurred within 7 days of receipt of a second dose of an mRNA COVID-19 vaccine per million second doses administered through the week of June 11, 2021. The benefit-risk assessment was stratified by age group and sex. government site. Per million second doses of mRNA COVID-19 vaccine administered to males aged 1229 years, 11,000 COVID-19 cases, 560 hospitalizations, 138 ICU admissions, and six deaths due to COVID-19 could be prevented, compared with 3947 expected myocarditis cases after COVID-19 vaccination (Table 2). Scilit | Article - Myocarditis and pericarditis associated with SARS Incidence Rates and Rate Ratios of Myocarditis in Vaccinated Individuals Compared With Control Groups. According to the CDC, as of June 23, 2021, more than 177 million people had received at least one dose of a COVID-19 vaccine in the U.S. A non-peer-reviewed retrospective paper, released as a pre-print, analyzed the rate of post-vaccination cardiac myocarditis in children aged 12-15 and 16-17 years who had received mRNA COVID . The EUA fact sheets should be provided before vaccination; in addition, CDC has developed patient and provider education materials about the possibility of myocarditis and symptoms of concern, to ensure prompt recognition and management of myocarditis. Myocarditis With COVID-19 mRNA Vaccines | Circulation The numbers of events per million persons aged 1229 years are the averages of numbers per million persons aged 1217 years, 1824 years, and 2529 years. Receipt of 2 doses of mRNA COVID-19 vaccine, compared with no vaccination. Case numbers have been rounded to the nearest hundred. Ranges calculated as 10% of crude VAERS reporting rates. Most people (95%) who develop myocarditis after receiving a COVID-19 mRNA vaccine have only mild symptoms that go away within a few days.5 Vaccine-linked myocarditis is less likely to cause lingering heart problems than myocarditis due to COVID-19 illness. Vaccination against COVID-19 provides clear public health benefits, but vaccination also carries potential risks. Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination PCORnet, United States, January 2021-January 2022. Based on ACIPs conclusion regarding the benefit-risk assessment on June 23, 2021, COVID-19 vaccination continues to be recommended for all persons aged 12 years under the FDAs EUA. Reported cases of the rare heart . Acute clinical courses were generally mild; among 304 hospitalized patients with known clinical outcomes, 95% had been discharged at time of review, and none had died. COVID vaccine-related myocarditis rare, usually mild, studies say As of now, the FDA Fact Sheet for Moderna's shot says "Myocarditis and pericarditis have occurred . Results: Myocarditis linked with COVID-19 illness may also be more severe because these patients are usually older and have other health conditions that increase their risk of complications. 2022 May 24;327(20):2019-2020. doi: 10.1001/jama.2022.5131. Main outcomes and measures: After reports of myocarditis and pericarditis in mRNA vaccine recipients, which predominantly occurred in young males after the second dose, an ACIP meeting was rapidly convened to review reported cases of myocarditis and pericarditis and discuss the benefits and risks of mRNA COVID-19 vaccination in the United States. https://gis.cdc.gov/grasp/COVIDNet/COVID19_3.html. A., & American Heart Association Pediatric Heart Failure and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young and Stroke Council (2021). The benefits (prevention of COVID-19 disease and associated hospitalizations, ICU admissions, and deaths) outweighed the risks (expected myocarditis cases after vaccination) in all populations for which vaccination has been recommended. doi: 10.1001/jamanetworkopen.2022.18505. Myocarditis is an inflammation of the heart muscle; if it is accompanied by pericarditis, an inflammation of the thin tissue surrounding the heart (the pericardium), it is referred to as myopericarditis. Online ahead of print. The EUA has been modified to include information on myocarditis after receipt of mRNA COVID-19 vaccines. References to non-CDC sites on the Internet are FLEG: The NHLBI has a strong history of conducting and funding research on myocarditis. Vaccination prevents most hospitalizations and deaths due to COVID-19. The vaccine product-specific EUA fact sheet should be provided to all vaccine recipients and their caregivers before vaccination with any authorized COVID-19 vaccine. Moderna said the majority of the infections were mild. Myocarditis Cases Reported After mRNA-Based COVID-19 - PubMed Questions or messages regarding errors in formatting should be addressed to The CONNECTS-Collaborative Cohort of Cohorts for COVID-19 Research (CONNECTS-C4R) trial is enrolling 50,000 people to determine factors that may predict disease severity and long-term side effects of COVID-19. Importance: Comparison of COVID-19 Vaccine-Associated Myocarditis and Viral Myocarditis Pathology. Another study is enrolling 500 survivors of COVID-19 to monitor their hearts for long-term effects of COVID-19, using cardiac MRI and echocardiography scans. N Engl J Med 2009;360:152638. Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military. *** The highest reporting rates were among males aged 1217 years and those aged 1824 years (62.8 and 50.5 reported myocarditis cases per million second doses of mRNA COVID-19 vaccine administered, respectively). Study: Myocarditis risk 2 to 3 times higher from Moderna than Pfizer Posts making claims regarding the mortality rate of children diagnosed with COVID-19-linked myocarditis are viewable here, here. FLEG: The CDC (Centers for Disease Control and Prevention) recommends COVID-19 vaccination for children as young as 6 months. New information for parents on myocarditis and COVID-19 vaccines B, For the mRNA-1273 vaccine, there were 116 reported cases of myocarditis with known date for symptom onset and dose after 78158611 first vaccination doses and 311 reported cases after 66163001 second vaccination doses. Dr Schlaudecker reported receiving grants from Pfizer and receiving personal fees from Sanofi Pasteur. ** https://www.cdc.gov/mis/hcp/index.html, https://www.ahajournals.org/doi/10.1161/CIR.0000000000000239?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#d3e785external icon. Figure 1.. Cases of Myocarditis After mRNA-Based, Figure 1.. Cases of Myocarditis After mRNA-Based COVID-19 Vaccination by Age at Onset of Myocarditis, Figure 2.. Cases of Myocarditis After mRNA-Based, Figure 2.. Cases of Myocarditis After mRNA-Based COVID-19 Vaccination by Time From Vaccination to Symptom, MeSH <> FDA requires that vaccine providers report to VAERS vaccination administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of a COVID-19 vaccine under an EUA. Centers for Disease Control and Prevention. For children ages 6 months to 2 years, efficacy was 43.7 percent, and in children ages 2 to 6, it was only 37.5 percent. Page last updated: Researchers also looked at rates per million doses and the rate was 35.6 cases per million for Moderna and 12.6 per million for Pfizer-;an almost threefold increase after Moderna shots vs.. Epidemiology of Myocarditis and Pericarditis Following mRNA Vaccination by Vaccine Product, Schedule, and Interdose Interval Among Adolescents and Adults in Ontario, Canada. Overall, the investigators found 2.13 myocarditis cases per 100,000 peopleagain, about a 0.002% incidencewith the highest incidence in men 16 to 29 years old, where it was 10.69 cases per 100,000 people, or a 0.011% incidence (95% CIs, 1.56 to 2.70 and 6.93 to 14.46, respectively). <>/Metadata 2557 0 R/ViewerPreferences 2558 0 R>> MMWR. Myocarditis rates from Vaccine Safety Datalink (VSD), based on electronic health records, were also evaluated. Members of the Advisory Committee on Immunization Practices COVID-19 Vaccines Safety Technical Work Group: Robert Hopkins, National Vaccine Advisory Committee; Kathryn Edwards, Vanderbilt University School of Medicine; Lisa Jackson, Kaiser Permanente Washington Health Research Institute; Jennifer Nelson: Kaiser Permanente Washington Health Research Institute; Laura Riley, American College of Obstetricians and Gynecologists; Patricia Whitley-Williams, National Medical Association; Tatiana Beresnev, National Institutes of Health; Karen Farizo, Food and Drug Administration; Hui Lee Wong, Food and Drug Administration; Judith Steinberg, U.S. Department of Health and Human Services; Matthew Clark, Indian Health Service; Mary Rubin, Health Resources & Services Administration; Fran Cunningham, Veterans Administration; Limone Collins, Department of Defense. Acute Myocarditis and Pericarditis After m-RNA COVID-19 VaccinationsA CDC twenty four seven. Most patients with myocarditis or pericarditis who received care responded well to medicine and rest and felt better quickly. From the 1.8 million Moderna doses administered in Australia to 2 January 2022, there have been 40 reports of likely myocarditis and 52 reports of likely pericarditis [3]. Am J Cardiol 2021;149:95102. 2022 Jun 11;399(10342):2191-2199. doi: 10.1016/S0140-6736(22)00791-7. They help us to know which pages are the most and least popular and see how visitors move around the site. Even though the studies were among the largest vaccine trials in history, they were not large enough to detect very rare complications like myocarditis that occur only a few times per million vaccinations. Acta Paediatr 2021;110:220811. * Persons who lack the listed symptoms but who meet other criteria may be classified as subclinical myocarditis (probable or confirmed). Using the Dallas criteria (Aretz HT, Billingham ME, Edwards WD, et al. Myocarditis. %PDF-1.7 Myocarditis related to COVID-19 vaccines seems to be caused by the bodys immune response to vaccination. Because of uncertainty in the accuracy of myocarditis reporting, given that reviews are ongoing, and some cases might not have been reported yet, myocarditis reporting rates are presented as a range of values, calculated as 10% of the observed reporting rates. doi: 10.1001/jamanetworkopen.2022.53845. Informed by early reports, CDC prioritized rapid review of myocarditis in persons aged <30 years reported during May 1June 11, 2021; the 484 patient records in this subset were evaluated by physicians at CDC, and several reports were also reviewed with Clinical Immunization Safety Assessment Project investigators, including cardiologists. Most of the suspected myocarditis cases in that study developed after the second dose and were among males between 12 and 39 years old. Your chance of getting myocarditis after getting a COVID-19 vaccine is less than the chance of being struck by lightning during your lifetime. Since April, more than 1,000 cases of inflammation of the . FDA Is Looking Again at Heart Inflammation Linked to Moderna Vaccine The known risks of COVID-19 illness and its related, possibly severe complications, such as long-term health problems, hospitalization, and even death, far outweigh the potential risks of having a rare adverse reaction to vaccination, including the possible risk of myocarditis or pericarditis. A histopathologic definition and classification. Conflict of Interest Disclosures: Dr Creech reported receiving grants from the National Institutes of Health for the Moderna and Janssen clinical trials and receiving personal fees from Astellas and Horizon. (2022). Myocarditis Following COVID-19 - US News Health Regarding health equity considerations, racial and ethnic minority groups have higher rates of COVID-19 and severe disease*****; potential changes in vaccine policy, or anything that would affect vaccination coverage for adolescents or young adults, might disproportionately affect those groups with the highest rates of poor COVID-19 outcomes. Although Rare, New Data Suggests Higher Rate of Myocarditis - BioSpace 1 0 obj The risk after both doses of the Moderna vaccine in people age 18 to 39 was as much as 37 times as high as in the general population, and the rate after two doses of the Pfizer-BioNTech vaccine. Its important to remember that any vaccine can cause side effects. Six awards are related to COVID-19related myocarditis. Vaccine myocarditis risk reaches 1 in 10,000 for adolescent boys Among teenaged boys the group with the highest risk of myocarditis after COVID-19 vaccination the risk is between 2 and 5 times higher after SARS-CoV-2 infection than after vaccination.10, A study of children ages 12 to 17 in England estimated that COVID-19 vaccination prevented 4,500 hospitalizations, 300 ICU hospital stays, and 36 deaths during the summer of 2021 when infection rates were high.11, Children with myocarditis linked with vaccination are less likely to be hospitalized, admitted to the ICU, or need ventilator support, compared with children who had myocarditis after a COVID-19 diagnosis. 4 0 obj The benefit of vaccination against COVID-19 outweighs the potential risk of myocarditis and pericarditis. PMC Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. For more severe cases of myocarditis caused by a virus, such as SARS-CoV-2, people may need to stay in the hospital for a week or two often in the ICU. Paul Burton, M.D., Ph.D., shared that data has found that there have been 13.3 cases of myocarditis per 100,000 people who received the Moderna vaccine compared to 2.7 cases per 100,000 people. Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine They help us to know which pages are the most and least popular and see how visitors move around the site. Canadian public health authorities also found that the rate of myocarditis was higher for both Moderna. (Jolygon/iStock via Getty Images) The risk of developing myocarditis - an inflammation of the heart muscle - following a booster dose of the Pfizer COVID-19 vaccine is low, according to new research from Israel. 2023 Feb 1;6(2):e2253845. Using myocarditis cases reported to VAERS with onset within 7 days after dose 2 of an mRNA vaccine, crude reporting rates (i.e., using confirmed and unconfirmed cases) per million second dose recipients were calculated using national COVID-19 vaccine administration data as of June 11, 2021. Since June 2020, ACIP has convened 15 public meetings to review data on COVID-19 epidemiology and use of COVID-19 vaccines. We take your privacy seriously. Experts Say Risk of Myocarditis From Moderna Vaccine Is Low The text reads: "Myocarditis is irreversible. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Reporting rates of myocarditis > background rates for males (12-49 years, depending upon dose and manufacturer) and females (after dose 2, 12-29 . Expected vs. Mary Chamberland, Thomas Clark, Amanda Cohn, Frank DeStefano, Ruth Gallego, Alice Guh, Theresa Harrington, Fiona P. Havers, Lauri Hicks, Amelia Jazwa, Tara Johnson, Brian Kit, Paige Marquez, Sarah Mbaeyi, Elaine Miller, Hannah Rosenblum, Monica Parise, Kadam Patel, Pragati Prasad, David Shay, Jamila Shields, Christopher A. Taylor, Joshua Wong, CDC COVID-19 Response Team; Clinical Immunization Safety Assessment (CISA) Project; Vaccine Safety Datalink; Center for Biologics Evaluation and Research, Food and Drug Administration; Voting members of the Advisory Committee on Immunization Practices: Kevin A. Ault, University of Kansas Medical Center; Lynn Bahta, Minnesota Department of Health; Henry Bernstein, Zucker School of Medicine at Hofstra/Northwell Cohen Childrens Medical Center; Beth Bell, University of Washington, Seattle, Washington; Wilbur Chen, University of Maryland School of Medicine; Sharon E. Frey, Saint Louis University Medical School; Camille Kotton, Harvard Medical School; Sarah Long, Drexel University College of Medicine; Katherine A. Poehling, Wake Forest School of Medicine; Pablo J. Snchez, The Research Institute at Nationwide Childrens Hospital. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 2023 Mar 2:1-14. doi: 10.1007/s13181-023-00931-9. Wong HL, Hu M, Zhou CK, Lloyd PC, Amend KL, Beachler DC, Secora A, McMahill-Walraven CN, Lu Y, Wu Y, Ogilvie RP, Reich C, Djibo DA, Wan Z, Seeger JD, Akhtar S, Jiao Y, Chillarige Y, Do R, Hornberger J, Obidi J, Forshee R, Shoaibi A, Anderson SA. The rates of myocarditis cases were highest after the second vaccination dose in adolescent males aged 12 to 15 years (70.7 per million doses of the BNT162b2 vaccine), in adolescent males aged 16 to 17 years (105.9 per million doses of the BNT162b2 vaccine), and in young men aged 18 to 24 years (52.4 and 56.3 per million doses of the BNT162b2 . For the BNT162b2 vaccine, there were 114246837 first vaccination doses and 95532396 second vaccination doses; and for the mRNA-1273 vaccine, there were 78158611 and 66163001, respectively. As of June 11, 2021, approximately 296 million doses of mRNA COVID-19 vaccines had been administered in the United States, with 52 million administered to persons aged 1229 years; of these, 30 million were first and 22 million were second doses. They suggest the rates of myocarditis after the Moderna-NIAID vaccine may be two-and-a-half times higher. A., Christakis, D. A., Cowell, L. G., Draper, C., Ghildayal, N., Harris, A. M., Kappelman, M. D., Ko, J. Y., Mayer, K. H., Nagavedu, K., Oster, M. E., Paranjape, A., Puro, J., Ritchey, M. D., Gundlapalli, A. V. (2022). [Preprint]. See this image and copyright information in PMC. Researchers added together cases after first and second doses to reach a total rate of 77 cases per million in this male age group triggered by vaccination, a sixth that seen after infection. All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest.
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